MANUFACTURER: ARISTOPHARMA LTD.
|Precautions||Patient with hypothyroidism; history of hereditary muscular disorders or muscular toxicity with another HMG-CoA reductase inhibitor or fibrates; excessive alcohol consumption, history of liver disease, severe respiratory failure.|
|Indication||Hypercholesterolaemia, Mixed dyslipidaemia|
|Contradiction||Active liver disease, including unexplained, persistent elevations of serum transaminases; myopathy. Severe renal impairment (CrCl <30 mL/min). Pregnancy and lactation.|
|Adult Dosage||"Adult: 20 mg once daily. Child:Heterozygous familial hypercholesterolaemia: Initially, 5 mg once daily."|
|Side Effects||Myopathy, myalgia, diabetes mellitus, haematuria, proteinuria, interstitial lung disease, liver enzyme abnormalities, increased creatine phosphokinase levels.|